Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats
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چکیده
منابع مشابه
Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.
AIM The present study was designed to investigate the activity of two glibenclamide derivatives on glucose concentration. An additional aim was to identify the biodistribution of glibenclamide derivatives in different organs in a diabetic animal model. METHODS The effects of two glibenclamide derivatives on glucose concentration were evaluated in a diabetic animal model. In addition, glibencl...
متن کاملComparison between hypoglycemic effects of Cuminum cyminum L. seeds and glibenclamide in diabetic rats
The purpose of this research was to compare the anti-hyperglycemic effect of Cuminum cyminum L. and glibenclamide, a known antidiabetic drug, in diabetic rats. After collection and taxonomic identification of plant, alcoholic extract of seeds prepared suxhlet apparatus respectively. The animals were made diabetic by using streptozotocin (70 mg/kg, i.p.). The diabetic rats were administrated int...
متن کاملComparison between hypoglycemic effects of Cuminum cyminum L. seeds and glibenclamide in diabetic rats
The purpose of this research was to compare the anti-hyperglycemic effect of Cuminum cyminum L. and glibenclamide, a known antidiabetic drug, in diabetic rats. After collection and taxonomic identification of plant, alcoholic extract of seeds prepared suxhlet apparatus respectively. The animals were made diabetic by using streptozotocin (70 mg/kg, i.p.). The diabetic rats were administrated int...
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OBJECTIVE Since antiquity bitter melon has been in use for treating diabetes but clinical trials show conflicting results about its usefulness. The present study aims to asses and compare the hypoglycemic and antiatherogenic effects as well as the safety of two different doses of bitter melon with glibenclamide. METHODS A total of 95 participants were randomized into 3 groups; group I and gro...
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Diabetes mellitus is one of the serious global health problems affecting a significant proportion of both developed and developing countries. Overproduction of free radicals and oxidative stress has been associated with the development of diabetic complications. In the present study, the antioxidant effects of metformin (MET), glibenclamide (GLI), and repaglinide (REP) were evaluated in alloxan...
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ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2012
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2012.028